However, studies have reported that down-regulation of SNX1 or SNX2 is associated with a decrease in total MET levels in lung cancer cells, while another study has reported that a decrease in SNX1 reduces cell membrane presence and leads to a concomitant increase in intracellular compartments’ distribution of the receptor in A549 lung cancer cells [24,27]. This evidence concerns the gene SNX2 and lung carcinoma.