Others have demonstrated that SNX1 overexpression contributes to a reversion of EMT in gastric cancer cells [43], while the knockdown of SNX5 in clear-cell renal-cell carcinoma cells promotes it [44], supported by changes in the expression of EMT markers such as Vimentin, Snail, E-cadherin, Claudin-1, or ZO-1 (zonula occludens-1). The gene discussed is CLDN1; the disease is clear cell renal carcinoma.