SNX2 and lung carcinoma: Despite a limited knowledge of a link between SNX and MET, a constitutive and direct interaction between SNX2 and MET has been identified through two-hybrid screening [23], and a study demonstrated that silencing SNX2 in lung cancer EBC-1 cells led to reduced MET protein levels and phosphorylation, contributing to overcoming resistance to anti-EGFR drugs [24].