NPPA and cardiac hypertrophy: have reported that EH-mediated end-organ injuries, such as cardiac hypertrophy in rats subjected to a hypertensive condition and salt stimulation, result from higher levels of H3K4me3 and AcH4, alongside reduced levels of H3K9me3 and H3K27me3 in the overexpressed atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) promoters (91).