Increased circulating levels of fibrinogen (19, 20, 40, 41), D-dimer (20, 23, 40), vWF (20, 42–44), AT-III (19–21, 44, 45), protein C-protein S complex (21, 22, 41, 45), and PAI-1 (19, 20, 41) were reported together with changes of additional coagulation factors and hemostatic tests (19–21, 41, 43, 46) in several cross-sectional comparisons of patients with Cushing’s syndrome with healthy subjects. Here, SERPINC1 is linked to Cushing syndrome due to macronodular adrenal hyperplasia.