With five determinants, including "day" (test date), "hgb" of hbA1c value (diabetic biomarker), "BNP" of NT-proBNP value (HF biomarker), "degree1" (polynomial regression for hbA1c), and "degree2" (polynomial regression for NT-proBNP), phope.py is a versatile biomarker prediction tool designed for patients [98]. Here, NPPB is linked to hydrops fetalis.