In addition, Enzyme-linked immunosorbent assay (ELISA) indicated that “Bovine serum albumin (BSA)-advanced glycation end (AGE)” enhanced IL-6 expression through MAPK-ERK action (MAPK-ERK and MyD88 transduced NF-κB signaling pathways), and studies (both in vitro and in vivo) have demonstrated that IL-6 played a crucial role in regulating the immune response in MS (Janssens et al., 2015; Shen et al., 2019). This evidence concerns the gene MYD88 and myeloid sarcoma.