IL6 and atherosclerosis: The anti-inflammatory effects of statins have been confirmed in experimental and clinical settings, and their inhibition of inflammatory responses not only plays a positive role in atherosclerosis, but also affects the expression of cytokines, such as TNF-α, IL-1, and IL-6, by reducing the adhesion and activation of inflammatory cells, and then repairing the endothelial damage of coronary microvessels, effectively improving myocardial ischemia and CMVD (52, 53).