The α4β2 and α7 subtypes are the most common nAChRs in the CNS and are linked to hyperactivity, aggression, and anxiety (Ross et al., 2000; Champtiaux et al., 2003; King et al., 2004; Lewis et al., 2015; Picciotto et al., 2015), behavioral features also common to rabies infection (Jackson, 2016b). Here, IGKV2D-24 is linked to Anxiety.