TRPV1 and specific granule deficiency: Shaoyao Gancao Decoction considerably inhibits the NGF/TRPV1/COX-2 signaling pathway, which is responsible for central hyperalgesia migraine. This indicates that the molecular mechanism by which SGD alleviates migraine symptoms might be associated with the central hyperalgesia neurotransmitter, which controls the pathophysiology of migraine.