Treatment with TREM1 modulation in C57BL/6 J male mice and BV2 cells revealed potential therapeutic insights for chronic migraine, while interventions including Dl-3-n-butylphthalide (NBP), Wuzhuyu Decoction, AMPK activator, UA, and RUT demonstrated varied mechanisms in reducing migraine severity and neuroinflammation across different mouse models and cell lines. Here, TREM1 is linked to migraine disorder.