CREB1 and migraine disorder: Perampanel inhibited PACAP expression in an in vitro research by inhibiting the cAMP/PKA/CREB pathway.However, the mechanism by which perampanel affects the cAMP/PKA/CREB pathway is complex and uncertain. Studying the protective benefits of perampanel against diseases like migraine can shed light on the causes of nervous system problems and aid in developing effective treatments.