TP53 and B-cell chronic lymphocytic leukemia: Among different recurrent aberrations and somatic gene mutations, the mutation status for TP53, and/or deletion of 17p/TP53 and the mutation status of the immunoglobulin heavy chain (IGH) locus variable region (IGHV) have been extensively tested for their prognostic and predictive significance and are recommended as standard diagnostics for CLL in WHO-HAEM5.