While translocations involving the IGH locus affect less than 5 % of cases of CLL, t(11;14)(q13;q32) leading to IGH::CCND1 juxtaposition, in the setting of a small B-cell neoplasm, is diagnostic of mantle cell lymphoma, and t(14;18)(q32;q21) leading to IGH::BCL2 juxtaposition is typical for leukaemic follicular lymphoma [1]. The gene discussed is CCND1; the disease is B-cell chronic lymphocytic leukemia.