Taking into account their variable morphology but homogeneous biological features and gene expression patterns, “double hit” cases with dual MYC and BCL2 rearrangements are designated diffuse large B-cell lymphoma/high-grade B-cell lymphoma with MYC and BCL2 rearrangements (DLBCL/HGBL-MYC/BCL2). The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.