An IG locus is the MYC partner in 50% of the cases, the most common being t(8;14)(q24;q32)/IGH::MYC. The mutational profile of these lymphomas is characterized by somatic variants in genes commonly altered both in FL and transformed lymphomas or Burkitt lymphoma (BL) such as CREBBP, KMT2D, EZH2, SI, TNFRSF14, BCL2, MYC, CCND3 and TP53 [14, 15]. The gene discussed is EZH2; the disease is lymphoma.