The genomic profile of MCL is characterized by losses in 1p22-p13, 6q, 9p21 (CDKN2A/B), 8p, 9q22-q31, 10p15-p13, 13q14 (RB1), 13q33-q34, 19q, and gains in 3q25-q29, 7p, 8q24 (MYC), 10p12 (BMI), and 13q31 (MIR17HG)[11]. The gene discussed is RB1; the disease is mantle cell lymphoma.