The mutational landscape of MCL is defined by alterations in genes involved in cell cycle control (CCND1, CDKN2A/B, CDK4, and RB1), DNA damage response (TP53, ATM, and MYC), epigenetic modulators (KMT2D, SMARCA4, and NDS2), NOTCH pathway (NOTCH1 and NOTCH2), and NF-κB signalling (BIRC3, NFKBIE, and TNFAIP3)[11]. Here, RB1 is linked to mantle cell lymphoma.