Lymphoplasmacytic lymphoma (LPL) is characterized by MYD88 (most of them MYD88L265P variant) and CXCR4 somatic mutations in around 96% and 35% of patients with IgM LPL/Waldenström Macroglobulinemia (WM) [6]. This evidence concerns the gene LPL and lymphoplasmacytic lymphoma.