TLX1 activation is frequently associated with a cortical immunophenotype; LMO2/LYL1 and HOXA subtypes are prevalent in ETP-ALL/LBL and are frequently associated with mutations activating JAK-STAT signaling; NUP214::ABL fusions are more prevalent in the TLX1/TLX3 subtype [36, 37] (Sin et al. 2021). This evidence concerns the gene LYL1 and acute lymphoblastic leukemia.