LRRK2 and Parkinson disease: The Comparative Toxicogenomics Database (CTD) [124] lists 78 chemicals interacting with LRRK2 (http://ctdbase.org/detail.go?type=gene&acc=120892), with the most interactions belonging to several chemicals, including three pesticides often associated with PD: paraquat, maneb and rotenone (none of which, however, are approved for use in Europe), MPP+ (commonly associated with PD), as well as manganese and magnesium, benzo(a)pyrene and some biological molecules (lipopolysaccharides, adenosine triphosphate) and a steroid (corticosterone).