For example, the penetrance of mutations in beta-glucocerebrosidase (GBA), the most frequent risk factor for Parkinson disease (PD), was estimated as 7.6 %, 13.7 %, 21.4 %, and 29.7 % at 50, 60, 70, and 80 years, respectively [2]. This evidence concerns the gene GBA1 and Parkinson disease.