KCNQ2 and early-infantile DEE: For Ohtahara syndrome (early infantile epileptic encephalopathy [EIEE]), a number of different genetic causes have been found in recent years, including genes for a neuronal voltage-sensitive potassium channel (KCNQ2), a sodium channel of excitatory neurons (SCN2A), and a synaptic protein involved in the exocytosis of neurotransmitters (STXBP1), among numerous other rare genes [7].