These factors include GCS, hypertension, COPD, dependent activity, high nursing needs, low level of consciousness, tachypnoea, gastrointestinal infections, detection rate of enterococcus, heart rate, PaO2, ALT, blood lactate, platelets, pH, MFI of CD86 in NKT cells, CD4+, S100 β, THRR index <1.09, mean value for rSO2 <55%, and ACTH. This evidence concerns the gene POMC and chronic obstructive pulmonary disease.