In addition, Du et al. confirmed that AS patients with sacroiliitis and other arthritis conditions (e.g., knee and neck) have higher serum IL-6 levels and that IL-6 levels are significantly related to CT image classifications of sacroiliitis through case–control studies, suggesting that IL-6 has a significant effect on the progress of bony impairment in AS patients (11). This evidence concerns the gene IL6 and arthritic joint disease.