CD4 and neoplasm: In summary, our data brings insight in the importance of BCG immunotherapy against melanoma, demonstrating that the intratumoral treatment with BCG in C57BL/6 mice induces the recruitment of a robust inflammatory cells infiltrate (M1-like tumor-associated macrophages, neutrophils, dendritic cells, CD4+ and CD8+ T cells, NK and NKT cells) and polarize the TME to a “hot” profile (antitumoral) associated with tumor control.