One potential Importantly, a strong positive correlation between antitumor cytokine expression levels and intratumoral infiltration of immune cells (immature and mature DCs as well as CD4+ or CD8+ T cells) was observed where oAd/APP+DC treatment resulted in highest level of infiltration or retainment of these immune cells (Figures 3–5), further supporting the notion that inactivation of immune cells by immunosuppressive tumor milieu could be overcome by overexpression of antitumor cytokines. This evidence concerns the gene APP and neoplasm.