IL6 and Sepsis: Current research shows that HDL levels significantly decrease in sepsis patients (33, 36), a result matching ours, possibly because sepsis triggers a systemic inflammatory response, leading to the release of inflammatory cytokines like tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) (34), which inversely correlate with HDL (35), suggesting that inflammatory factors may indirectly reduce HDL synthesis by inhibiting hepatic lipid metabolism.