More precisely, regardless of the sex steroid concentrations, the production of IFN production by pDCs following TLR7 stimulation is higher in subjects with a karyotype including two X chromosomes (prepubertal girls, adult women, and individuals assigned female at birth who identify as transgender) compared with subjects with a single X chromosome (prepubertal boys, adult men, individuals assigned male at birth who identify as transgender, and patients with Turner syndrome) (197). Here, TLR7 is linked to Turner syndrome.