Tumor-derived exosomes (TDEs) activate two independent pathways that enhance glycolysis via the NF-κB pathway: (1) Activated HIF-1α upregulates GLUT-1 expression, which increases glucose uptake into the macrophage; (2) Activated NOS2 increases NO production, which diverts pyruvate to the lactate pathway by inhibiting OXPHOS. This evidence concerns the gene HIF1A and neoplasm.