Even though experimental injection of endotoxin in women induces more cytokines than in men (105), and female cells express more innate pathogen sensors like TLR2, TLR4 and TLR7 (106, 107), females tend to have innate regulatory mechanisms producing relatively restrained complement activation, controlled proinflammatory cytokine secretion (“cytokine storm”), and better survival during sepsis (56, 57, 108). This evidence concerns the gene TLR4 and Sepsis.