If workplace-related inhalation challenge testing is not possible in a specialized facility and there is a strong suspicion of occupational asthma based on the medical history, a combination of objective signs of asthma or rhinitis and a positive skin test or the detection of specific IgE for the suspected trigger has a high predictive value for an occupational respiratory disease if it is a high molecular allergen source [8]. Here, IGHE is linked to asthma.