PIK3CA and Proteus syndrome: These disorders include congenital lipomatous overgrowth, vascular malformations, epidermal nevi, skeletal anomalies (CLOVES, PIK3CA variants), megalencephaly-capillary malformation (MCAP, also caused by PIK3CA variants), Proteus syndrome (AKT1 variants) and Smith-Kingsmore syndrome (MTOR variants).