The lipid accumulation observed in obesity is intricately linked to adiponectin secretion levels; elevated adiponectin levels are associated with a diminished risk of metabolic complications arising from obesity, while diminished levels of adiponectin are correlated with an increased susceptibility to metabolic irregularities, hypertension, and hypertriglyceridemia (Achari and Jain, 2017; Zhao et al., 2021). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.