TGFB1 and ablepharon macrostomia syndrome: In conclusion, a certain concentration of AMS not only does not cause damage to the body, but also has a protective effect on PF, which is specifically reflected in the fact that AMS can act on the target of TGF-β, interfere with EMT through the associated cytokine network, and improve the oxidative stress in the body to balance the production of ROS, Further, regulate the downstream TGF-β related signaling pathway.