It was found that β-catenin may compete with Smad7 after the construction of Smad7 cell lines, and at the same time reduce the inhibitory effect of AMS on EMT to a certain extent, and the same operation was performed in the rat PF model induced by intrapitoneal injection of 4.25% high glucose peritoneal permeate solution, and the results were also similar. Here, SMAD7 is linked to pemphigus foliaceus.