Our study revealed a downregulation of ACE2 in T1D Akita mice which is consistent with the previous observation in different experimental diabetic mice including diabetic Akita mice (Tikellis et al., 2003; Gurley et al., 2006; Wysocki et al., 2006; Wong et al., 2007; Oudit et al., 2010). This evidence concerns the gene ACE2 and type 1 diabetes mellitus.