A plethora of evidence suggest the pathogenic role of proinflammatory cytokine IL17 and protective role of anti-inflammatory cytokine IL10 in diabetes and hypertension (Gunnett et al., 2002; Didion et al., 2009; Madhur et al., 2010; Weber et al., 2017; Qiu et al., 2021). The gene discussed is IL10; the disease is hypertensive disorder.