Multiple hypotheses have been proposed to explain the etiology of AD, encompassing the tau protein hypothesis, amyloid hypothesis, cholinergic hypothesis, oxidative stress (OS) hypothesis, neuroinflammation hypothesis, apoptosis hypothesis, neurotrophic hypothesis, endoplasmic reticulum (ER) stress hypothesis, excitotoxicity hypothesis, and mitochondrial dysfunction hypothesis etc (Liu et al., 2019a; Serrano-Pozo, Das, and Hyman, 2021; Zhang, Wang, et al., 2022b). This evidence concerns the gene MAPT and Alzheimer disease.