FOXP3 and autoimmune disease: Regulatory T cells, an inhibitory T lymphocyte subset characterized by the transcription factor Foxp3, plays a critical role in modulating the immune response to self and foreign antigens and helping to prevent autoimmune disease like MS and EAE (Viglietta et al., 2004; Huan et al., 2005; Brahmachari and Pahan, 2009).