FMR1 and fragile X-associated tremor/ataxia syndrome: Remarkably, CGG repeat expansions in FMR1 ranging from 55 to 200 repeats (premutations) were later found to be associated with two other disorders: Fragile X-associated premature ovarian insufficiency (FXPOI, also known as Premature Ovarian Failure 1 [POF1], MIM #311360) in females [13] and Fragile X-associated tremor ataxia syndrome (FXTAS, MIM #300623) in males [14].