WES performed in eczema patients with ichthyosis vulgaris from Ethiopia [21], in individuals with eczema and high IgE levels from Japan [22], and in adult-onset eczema patients from Korea [23] identified rare nonsense and missense mutations in a number of epidermal differentiation complex (EDC) genes, in ADAM33, DSG4, GTF2H5, EVPL, NLRP1, SPINK5, and CYP27A1. This evidence concerns the gene NLRP1 and Eczematoid dermatitis.