F2 and congenital rubella syndrome: (27) Patients with grade ≥2 CRS after anti CD19 CAR T infusion had increased prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, D-dimer, factor VIII, von Willebrand factor (vWF), and decreased platelet count and antithrombin levels compared to those with lower grade or no CRS, suggesting that endothelial activation was predictive for greater CRS severity and development of disseminated intravascular coagulopathy (DIC).