ANGPT1 and acute lymphoblastic leukemia: (95) In two separate retrospective analyses of patients treated with CAR T for B-ALL, patients who developed severe neurotoxicity were more likely to have laboratory findings consistent with DIC and capillary leak, lowers levels of Ang-1, higher levels of Ang-2, and a higher Ang-2:Ang-1 ratio suggestive of endothelial activation.