(1) The anti-CD19 CAR T cell therapies tisagenlecleucel (tisa-cel) and axicabtagene autoleucel (axi-cel) were the first to receive regulatory approval in 2017 after demonstrating unprecedented efficacy for the treatment of relapsed/refractory pediatric B-cell acute lymphoblastic leukemia (B-ALL) and large B-cell lymphoma (LBCL). Here, CD19 is linked to acute lymphoblastic leukemia.