Despite demonstrating the ability of leukemia cells carrying the PLZF::RARα fusion to fully differentiate with both ex vivo and in vivo ATRA treatment, the clinical reality is that APL with this rare fusion is commonly considered ATRA-insensitive and is linked to an unfavorable prognosis (10–12, 55). The gene discussed is ZBTB16; the disease is acute promyelocytic leukemia.