BCAT1 and glioblastoma: The glutamate-synthesizing aminotransferase BCAT1 (produces glutamate from α-ketoglutarate) may overproduce glutamate in tumors and an upregulation of BCAT1, that may in part be driven by hypoxic conditions of fast-growing glioblastoma (60), was associated with poor patient survival (61, 62).