ABCC2 and neoplasm: For instance, doxorubicin, vincristine, and cyclophosphamide are substrates of ATP Binding Cassette transporters (i.e., Pg-P, MRP2, and BCRP, which are encoded by ABCB1, ABCC2, and ABCG2, respectively), whose overexpression leads to the extrusion of these drugs from tumor cells, resulting in the occurrence of intrinsic or acquired multidrug resistance[33,34].