In addition, U3-1287/AMG888, in combination with radiation, can enhance the efficacy of radiotherapy as U3-1287/AMG888 could inhibit basal and radiation-induced activation of HER3, AKT, rpS6, and MAPK in NSCLC and head and neck squamous carcinoma (HNSCC)[68]. This evidence concerns the gene ERBB3 and head and neck squamous cell carcinoma.