Mechanistically, pentoxifylline showed anticancer activity by reducing tumorigenesis and cell proliferation via modulation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and protein kinase B (Akt) pathways[23], and inducing apoptosis and cell cycle arrest in breast[24], liver[25], and colorectal[26] cancer cells. Here, AKT1 is linked to cancer.