Additionally, this work demonstrated that pentoxifylline decreased STAT3 expression levels in one of the MDR cell lines, which corroborates previous studies demonstrating that pentoxifylline impairs cancer cells’ ability to migrate through the downregulation of STAT3 signaling in B16-F10 murine melanoma[51] and in A375 human melanoma cells[52]. The gene discussed is STAT3; the disease is cancer.