As mentioned above, this effect was also observed for the natural MYB inhibitor withaferin A. In addition, mebendazole was active (in vitro and in vivo) against MYB-regulated T-cell acute lymphocytic leukemia protein 1 (TAL1) 5’super-enhancer (5’SE) mutant T-ALL Jurkat and patient-derived cells by enhanced MYB degradation[245]. The gene discussed is MYB; the disease is acute lymphoblastic leukemia.