The combination of the COX-2 inhibitor CAY10404 with the dual PI3K/mammalian target of rapamycin (mTOR) inhibitor PI-103 circumvented the anti-apoptotic mechanisms and showed high antiproliferative and apoptosis-inducing effects on Huh1, Huh7, and Alexander HCC cells[165]. The gene discussed is PIK3CG; the disease is hepatocellular carcinoma.