In addition, the suppression of MYB in acute lymphoblastic leukemia (ALL) cells transfected with doxycycline-regulated lentiviral sh-c-Myb sensitized these cells to treatment with DNA-targeting drugs (doxorubicin and the antimetabolite 6-mercaptopurine) by downregulation of anti-apoptotic BCL2[58]. The gene discussed is BCL2; the disease is acute lymphoblastic leukemia.