MYBL2 and neoplasm: Murine ID8 OC was resistant to anti-PD-1 antibody (BE0273) in vivo treatment due to MYBL2-mediated upregulation of C-C-motif chemokine ligand 2 (CCL2) followed by enhanced recruitment of immunosuppressive macrophages; however, suppression of MYBL2 by shMYBL2 sensitized these tumors to anti-PD-1 treatment by reducing tumor-associated macrophage (TAM) numbers[143].