The combination of the alkaloid berberine with oligomeric proanthocyanidines revealed synergistic antiproliferative and pro-apoptotic effects in RKO and HT-29 CRC cells based on MYB and AKT downregulation, thus indicating an important role of MYB in the eminent chemoresistance-associated PI3K-AKT signaling pathway[225]. Here, AKT1 is linked to colorectal carcinoma.