Trametinib-induced FBW7-dependent Mcl-1 ubiquitination and degradation enhanced apoptosis in colorectal cancer cell lines[54], while Tolksdorf et al. showed that Mcl-1 silencing may overcome the resistance of melanoma cells against TRAIL-armed oncolytic adenovirus[55]. The gene discussed is TNFSF10; the disease is colorectal cancer.