For several cell lines, including NSCLC cells and in our study, the cytotoxic effect of TRAIL receptors was most efficient when distributed in lipid rafts[22,23,78], while we also demonstrated that TRAIL sensitivity was particularly induced via TRAIL-R1, which was redistributed towards the lipid rafts, similar to gastric cancer[68]. This evidence concerns the gene TNFSF10 and non-small cell lung carcinoma.