SOD1 and amyotrophic lateral sclerosis: Interestingly, murine SOD1 is resistant to intermolecular prion-like seeding of SOD1 [15] and does not co-aggregate with transgenic human SOD1 in murine models of SOD1-associated ALS [28], a possible consequence of this region exhibiting the least sequence similarity between mice and humans across the SOD1 sequence [29].