NUBPL and early-onset autosomal dominant Alzheimer disease: LC, PC, AD1, and AD2 are the clinico-genomic datasets; LC Lung cancer (European and East Asian populations), PC Prostate cancer (European and African American populations), AD1 Alzheimer’s disease (European and Latin American populations), AD2 Alzheimer’s disease (European and African American populations), LR Logistic regression, DL Deep learning; Mix0, Mix1, Mix2, Ind1, Ind2, NT, and TL are the machine learning experiments outlined in Table 2