<h4>Background</h4>Investigating the unexplored territory of lncRNA m6A modification in colorectal cancer (CRC) vasculature, this study focuses on LINC01106 and YTHDF1.<h4>Methods</h4>Clinical assessments reveal upregulated LINC01106 promoting vascular generation via the miR-449b-5p-VEGFA pathway.<h4>Results</h4>YTHDF1, elevated in CRC tissues, emerges as an adverse prognostic factor. This evidence concerns the gene YTHDF1 and colorectal cancer.