PRMT1 and obesity due to melanocortin 4 receptor deficiency: Given the critical roles of gut hormones and peptides in regulating physiological functions, such as nutrient intake, lipid adsorption, and glucose homeostasis, and the involvement of EECs in obesity and diabetes, our results suggest that targeting PRMT1 may offer a novel strategy to control EEC specification to prevent and/or treat human metabolic diseases.