Similarly, the level of Tnfsf11 and Tnfrsf11a encoding respectively for the secreted factor RANKL and its receptor, RANK, involved in the oncogenesis of Brca1 mutation-driven breast cancer, was not altered in the absence of Itgα6 (Additional File 2: Fig. S2E; [34]). The gene discussed is BRCA1; the disease is breast cancer.