Here, we explore the role of the α6-integrin in mammary tumorigenesis, using an established mouse model of basal-like cancer, the Blg-Cre;Brca1F/F;Trp53F/F mice, that develop invasive tumors phenocopying BRCA1-deficient human breast tumors at the molecular and morphological level [14]. The gene discussed is BRCA1; the disease is breast neoplasm.