NRSN2 and osteosarcoma: In particular, Bone Marrow Mesenchymal Stem Cells-Derived Extracellular Vesicles (BMSC-EVs) were found able to promote proliferation, invasion and migration of osteosarcoma cells via the MALAT1/miR-143/NRSN2/Wnt/beta-catenin axis both in vitro and in vivo, as detailed in a next section.