In particular, MALAT1 shares miR-144-3p binding sites with ROCK1 and ROCK2, two small G proteins, belonging to the Rho family, regulating cytoskeletal activities and pericellular matrix degradation involved in cell movement, proliferation and migration/invasion; indeed, the ceRNET MALAT1/miR-144-3p/ROCK1/2 is a molecular mechanism contributing to the ability of the lncRNA to promote tumor growth and lung metastasis, as demonstrated in vivo [125]. Here, ROCK1 is linked to neoplasm.