Methods that pool information from multiple sources can help with these challenges.<h4>Methods</h4>We compared three approaches for developing clinical prediction models for population screening based on an example of discriminating a rare form of diabetes (Maturity-Onset Diabetes of the Young - MODY) in insulin-treated patients from the more common Type 1 diabetes (T1D). The gene discussed is INS; the disease is type 1 diabetes mellitus.