After excluding SNPs with P-HEIDI < 0.05 and FDR-adjusted P-values > 0.05 via SMR analysis, we identified a total of 14 genes that have a causal relationship with lung cancer, including FUBP1, RP11-218F10.3, CTD-2012J19.1, BTN2A2, TRIM31, FLOT1, LINC00243, HLA-DQA1, HLA-DQB1, HLA-DQB1-AS1, HLA-DQB2, RNASET2, AC011330.5 and SECISBP2L. This evidence concerns the gene HLA-DQB1 and lung cancer.