For lung squamous cell carcinoma, 9 genes were causally related, comprising U91328.19, FLOT1, LINC00243, HLA-DQA1, HLA-DQB1, HLA-DQB1-AS1, HLA-DQB2, ZNF483 and BLOC1S2. The gene discussed is BLOC1S2; the disease is squamous cell lung carcinoma.