In order to clarify the causal relationship between HYKK (AGPHD1) and lung squamous cell carcinoma, a conditional Logistic regression model was used to calculate the OR value and 95%CI of lung squamous cell carcinoma associated with the use of candidate drugs, and the results were visualized by YangLab SMR visualization method (Fig. 3). Here, HYKK is linked to squamous cell lung carcinoma.