For lung squamous cell carcinoma, 11 genes were causally related, comprising COPA, NCSTN, U91328.19, GABBR1, IER3, HLA-DQB1-AS1, HLA-DQB2, ANKRD26, PKD2L1, PSMA4 and RAD51C. The gene discussed is IER3; the disease is squamous cell lung carcinoma.