HYKK and lung adenocarcinoma: In the replication cohort results, HYKK (AGPHD1) displayed varying degrees of colocalization evidence: for the non-small subtype, PP.H4 was 28.5%; for the lung adenocarcinoma subtype, PP.H4 was 35.2%; and for the lung squamous cell carcinoma subtype, PP.H4 was 98.9% (indicating strong evidence for colocalization since PP.H4 > 0.75).