Activated STAT3 within the tumor microenvironment induces the malignant transformation of relevant cells to immunosuppressive forms, such as M2-like tumor-associated macrophages, Tregs, and cancer-associated fibroblasts, thereby promoting cancer growth, expansion, and infiltration (Zou et al. 2020; Albrengues et al. 2015; Verdeil et al. 2019). This evidence concerns the gene STAT3 and neoplasm.