INS and obesity due to melanocortin 4 receptor deficiency: The relationship between obesity and the risk of sarcopenia is controversial, in this regard, it has been pointed out that excess body fat increases the risk of sarcopenia, due to greater oxidative stress (OxS), chronic inflammation (CI), insulin resistance, lipotoxicity and fatty infiltration in muscle cells (myosteatosis), which occurs in obesity, causing muscle atrophy [32, 33].